Non-invasive prenatal testing for aneuploidy: current status and future prospects
نویسندگان
چکیده
منابع مشابه
Non-invasive prenatal testing for aneuploidy: current status and future prospects.
Non-invasive prenatal testing (NIPT) for aneuploidy using cell-free DNA in maternal plasma is revolutionizing prenatal screening and diagnosis. We review NIPT in the context of established screening and invasive technologies, the range of cytogenetic abnormalities detectable, cost, counseling and ethical issues. Current NIPT approaches involve whole-genome sequencing, targeted sequencing and as...
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Discovery of cell free fetal DNA in 1997 has deeply changed the outlook of prenatal diagnosis approaches as most of the clinically established screening tests are not sensitive/specific enough while the current practical diagnostic tests are also invasive in their nature. The most common prenatal screening test is routinely practiced for the diagnosis of Down syndrome (DS) which includes a 10% ...
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ژورنال
عنوان ژورنال: Ultrasound in Obstetrics & Gynecology
سال: 2013
ISSN: 0960-7692
DOI: 10.1002/uog.12513